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Nat Genet. 2014 Jun;46(6):527-8. doi: 10.1038/ng.2992.

PARK2 orchestrates cyclins to avoid cancer.

Author information

1
1] Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. [2] Danish Cancer Society Research Center, Copenhagen, Denmark.
2
Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.

Abstract

Proper control of cyclin-dependent kinases ensures coordinated cell cycle progression and guards against tumorigenesis. A new study identifies the PARK2 E3 ubiquitin ligase as an important coordinator of G1/S-phase cyclin turnover and explains how mutations targeting this key cell cycle regulatory node contribute to a range of cancers.

PMID:
24866187
DOI:
10.1038/ng.2992
[Indexed for MEDLINE]

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