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Epidemiol Infect. 2015 Mar;143(4):857-63. doi: 10.1017/S0950268814001290. Epub 2014 May 27.

Genetic variants associated with susceptibility of Ashkenazi Jews to West Nile virus infection.

Author information

1
Institute of Genetics,Emek Medical Centre, Afula,Israel.
2
Department of Medicine D,Emek Medical Centre,Afula,Israel.
3
Clinical Research Unit,Emek Medical Centre,Afula,Israel.
4
Virology Laboratory,Rambam Health Care campus, Haifa,Israel.

Abstract

The epidemiology of West Nile virus (WNV) in Israel is different from other neighbouring countries in the Middle East where disease burden has been minimal. We analysed a cohort of Ashkenazi Jewish patients with symptomatic WNV infection (n = 39), and WNV-negative controls (n = 61), for nine genetic variants that has been suggested to be associated with susceptibility to WNV. Two single nucleotide polymorphisms were significantly more frequent in WNV-infected than non-infected individuals, rs7280422 (MX1) [odds ratio (OR) 4·05, 95% confidence interval (CI) 2·04-8·03, P < 0·001] and rs3213545 (OASL) (OR 1·85, 95% CI 1·03-3·3, P = 0·03). Genetic polymorphism may play a significant role in susceptibility to WNV infection in Ashkenazi Jews.

KEYWORDS:

West Nile virus

PMID:
24865988
DOI:
10.1017/S0950268814001290
[Indexed for MEDLINE]
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