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J Gen Physiol. 2014 Jun;143(6):679-92. doi: 10.1085/jgp.201311153.

Calmodulin regulation (calmodulation) of voltage-gated calcium channels.

Author information

1
Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
2
Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205Calcium Signals Laboratory, Department of Biomedical Engineering, Department of Neuroscience, and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 dyue@jhmi.edu.

Abstract

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca(2+) sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca(2+) signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca(2+) feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.

PMID:
24863929
PMCID:
PMC4035741
DOI:
10.1085/jgp.201311153
[Indexed for MEDLINE]
Free PMC Article

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