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J Biochem Mol Toxicol. 2014 Aug;28(8):378-85. doi: 10.1002/jbt.21574. Epub 2014 May 27.

Modulatory effects of curcumin on redox status, mitochondrial function, and caspace-3 expression during atrazin-induced toxicity.

Author information

1
Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.

Abstract

Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity was induced by oral administration of atrazine (400 mg/kg/day) for 3 weeks. Curcumin at a dose of 400 mg/kg/day was given simultaneously by oral route. Redox status, mitochondrial function, 8-hydroxydeoxyguanosine (8-OHdG) level by immunoassay, and caspace-3 expression by immunohistochemistry were evaluated. Curcumin showed significant cardiac protection with improvement of redox status, mitochondrial function, 8-OHdG level, caspase-3 immunoreactivity, and cardiac muscle degeneration. From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.

KEYWORDS:

Atrazine; Caspase-3; Curcumin; Mitochondrial Function; Oxidant/Antioxidant Status

PMID:
24863870
DOI:
10.1002/jbt.21574
[Indexed for MEDLINE]

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