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Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):449-55. doi: 10.1016/j.rec.2013.10.015. Epub 2014 Feb 26.

Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile.

Author information

1
Unidad de Prevención Cardiovascular, Instituto Aragonés de Ciencias de la Salud (I+CS), Zaragoza, Spain.
2
Instituto de Investigación Clínica (I+12), Hospital 12 de Octubre, Madrid, Spain; CIBER-ESP (Epidemiología y Salud Pública), Madrid, Spain. Electronic address: eandres@h12o.es.
3
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
4
Departamento de Prevención de Riesgos Laborales de General Motors España, Figueruelas, Zaragoza, Spain.
5
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States.

Abstract

INTRODUCTION AND OBJECTIVES:

To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.

METHODS:

Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/high-density lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.

RESULTS:

The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [β = 0.07], log homeostasis model assessment of insulin resistance index [β = 0.05], triglyceride/high-density lipoprotein cholesterol ratio [β = 0.23], and insulin [β = 0.44]), which remained after adjustment for metabolic equivalents-h/week.

CONCLUSIONS:

Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed.

KEYWORDS:

Cardiovascular risk; Inflamación; Inflammation; Insulin resistance; Resistencia a insulina; Riesgo cardiovascular; Sedentarismo; Sedentary lifestyle

PMID:
24863593
DOI:
10.1016/j.rec.2013.10.015
[Indexed for MEDLINE]

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