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Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):449-55. doi: 10.1016/j.rec.2013.10.015. Epub 2014 Feb 26.

Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile.

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Unidad de Prevención Cardiovascular, Instituto Aragonés de Ciencias de la Salud (I+CS), Zaragoza, Spain.
Instituto de Investigación Clínica (I+12), Hospital 12 de Octubre, Madrid, Spain; CIBER-ESP (Epidemiología y Salud Pública), Madrid, Spain. Electronic address:
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Departamento de Prevención de Riesgos Laborales de General Motors España, Figueruelas, Zaragoza, Spain.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States.



To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers.


Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/high-density lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance.


The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [β = 0.07], log homeostasis model assessment of insulin resistance index [β = 0.05], triglyceride/high-density lipoprotein cholesterol ratio [β = 0.23], and insulin [β = 0.44]), which remained after adjustment for metabolic equivalents-h/week.


Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed.


Cardiovascular risk; Inflamación; Inflammation; Insulin resistance; Resistencia a insulina; Riesgo cardiovascular; Sedentarismo; Sedentary lifestyle

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