Are lithium niobate (LiNbO3) and lithium tantalate (LiTaO3) ferroelectrics bioactive?

Mater Sci Eng C Mater Biol Appl. 2014 Jun 1:39:395-402. doi: 10.1016/j.msec.2014.03.026. Epub 2014 Mar 20.

Abstract

The use of functional materials, such as ferroelectrics, as platforms for tissue growth in situ or ex situ, is new and holds great promise. But the usage of materials in any bioapplication requires information on biocompatibility and desirably on bioactive behavior when bone tissue engineering is envisaged. Both requirements are currently unknown for many ferroelectrics. Herein the bioactivity of LiNbO3 and LiTaO3 is reported. The formation of apatite-like structures on the surface of LiNbO3 and LiTaO3 powders after immersion in simulated body fluid (SBF) for different soaking periods indicates their bioactive potential. The mechanism of apatite formation is suggested. In addition, the significant release of lithium ions from the ferroelectric powders in the very first minutes of soaking in SBF is examined and ways to overcome this likely hurdle addressed.

Keywords: Apatite; Bioactivity; Ferroelectrics; Lithium niobate; Lithium tantalate; Simulated body fluid (SBF).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apatites / chemistry
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Blood
  • Body Fluids / chemistry
  • Body Fluids / drug effects
  • Humans
  • Lithium / chemistry*
  • Lithium / pharmacology
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Molecular Structure
  • Niobium / chemistry*
  • Niobium / pharmacology
  • Oxides / chemistry*
  • Oxides / pharmacology
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • Tantalum / chemistry*
  • Tantalum / pharmacology

Substances

  • Apatites
  • Biocompatible Materials
  • Oxides
  • lithium tantalate oxide
  • Niobium
  • lithium niobate
  • Tantalum
  • Lithium