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Horm Res Paediatr. 2014;82(2):133-7. doi: 10.1159/000358084. Epub 2014 May 24.

Gonadotropin-dependent precocious puberty in an 8-year-old boy with leydig cell testicular tumor.

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Department of Pediatrics, Hospital S. João, Porto, Portugal.


Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.

[Indexed for MEDLINE]

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