Format

Send to

Choose Destination
See comment in PubMed Commons below
Horm Res Paediatr. 2014;82(2):133-7. doi: 10.1159/000358084. Epub 2014 May 24.

Gonadotropin-dependent precocious puberty in an 8-year-old boy with leydig cell testicular tumor.

Author information

1
Department of Pediatrics, Hospital S. João, Porto, Portugal.

Abstract

Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.

PMID:
24862970
DOI:
10.1159/000358084
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center