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J Surg Oncol. 2014 Jun;109(8):751-5. doi: 10.1002/jso.23581. Epub 2014 Feb 20.

Early experience with ultrasound features after intrabeam intraoperative radiation for early stage breast cancer.

Author information

1
Department of Women's Oncology, Moffitt Cancer Center, Tampa, Florida.

Abstract

BACKGROUND:

Intraoperative radiation therapy (IORT) is an emerging option for partial breast radiotherapy in select women with early stage breast cancer. We assessed short-term clinical and sonographic findings after breast conservation (BCT) and IORT.

METHODS:

An IRB-approved, single institution retrospective chart review was conducted of patients (pts) treated with BCT/IORT from 1/2011 to 6/2012. Follow-up clinical breast exams and ultrasounds (US) obtained 6 and 12 months after BCT/IORT were retrospectively reviewed by a single breast radiologist (JD) for sonographic findings. P values were calculated using McNemar's test, Wilcoxon Rank Sum Test, and Chi-square.

RESULTS:

Seventy-one pts underwent BCT/IORT and 38 pts had an US. All 38 pts had a seroma, 10/38 (26%) pts were symptomatic. Eighteen pts had deep tissue closure (DTC) of the lumpectomy cavity with 5/18 (28%) DTC pts being symptomatic at follow-up versus 5/33 (15%) without DTC (P = 0.296). At 6 months, DTC resulted in smaller seroma cavity volumes compared to those without DTC (P = 0.03).

CONCLUSION:

Presence of a seroma is commonplace post BCT/IORT; symptomatic seromas are uncommon. DTC generated smaller seromas. Longer follow-up with serial US performed in all BCT/IORT pts could be considered to document natural progression/regression of symptoms and seromas.

KEYWORDS:

breast conserving surgery; early stage breast cancer; intrabeam; intraoperative radiation; partial breast radiation

PMID:
24862923
DOI:
10.1002/jso.23581
[Indexed for MEDLINE]

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