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Interdiscip Top Gerontol. 2014;39:86-107. doi: 10.1159/000358901. Epub 2014 May 13.

Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging.

Author information

1
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USA.

Abstract

Aging is characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-associated diseases and death. One potential cause of aging is the progressive accumulation of dysfunctional mitochondria and oxidative damage with age. Considerable efforts have been made in our understanding of the role of mitochondrial dysfunction and oxidative stress in aging and age-associated diseases. This chapter outlines the interplay between oxidative stress and mitochondrial dysfunction, and discusses their impact on senescence, cell death, stem cell function, age-associated diseases and longevity.

PMID:
24862016
DOI:
10.1159/000358901
[Indexed for MEDLINE]

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