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Nucleic Acids Res. 2014 Jun;42(11):7028-38. doi: 10.1093/nar/gku415. Epub 2014 May 26.

Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark.

Author information

1
Fox Chase Cancer Center, Philadelphia, PA, 19111 USA.
2
The Wistar Institute, Philadelphia PA, 19104 USA.
3
Fox Chase Cancer Center, Philadelphia, PA, 19111 USA alexei.tulin@fccc.edu.

Abstract

Epigenetics are the heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. After mitosis, it is thought that bookmarking transcription factors remain at promoters, regulating which genes become active and which remain silent. Herein, we demonstrate that poly(ADP-ribose)polymerase-1 (PARP-1) is a genome-wide epigenetic memory mark in mitotic chromatin, and we further show that the presence of PARP-1 is absolutely crucial for reactivation of transcription after mitosis. Based on these findings, a novel molecular model of epigenetic memory transmission through the cell cycle is proposed.

PMID:
24861619
PMCID:
PMC4066802
DOI:
10.1093/nar/gku415
[Indexed for MEDLINE]
Free PMC Article

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