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Dev Growth Differ. 2014 Jun;56(5):410-24. doi: 10.1111/dgd.12136. Epub 2014 May 23.

Growth and differentiation of a long bone in limb development, repair and regeneration.

Author information

1
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama 6-3, Aoba-ku, Sendai, 980-8578, Japan.

Abstract

Repair from traumatic bone fracture is a complex process that includes mechanisms of bone development and bone homeostasis. Thus, elucidation of the cellular/molecular basis of bone formation in skeletal development would provide valuable information on fracture repair and would lead to successful skeletal regeneration after limb amputation, which never occurs in mammals. Elucidation of the basis of epimorphic limb regeneration in amphibians would also provide insights into skeletal regeneration in mammals, since the epimorphic regeneration enables an amputated limb to re-develop the three-dimensional structure of bones. In the processes of bone development, repair and regeneration, growth of the bone is achieved through several events including not only cell proliferation but also aggregation of mesenchymal cells, enlargement of cells, deposition and accumulation of extracellular matrix, and bone remodeling.

KEYWORDS:

bone; differentiation; fracture; growth; regeneration

PMID:
24860986
DOI:
10.1111/dgd.12136
[Indexed for MEDLINE]
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