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J Tradit Complement Med. 2014 Apr;4(2):89-92. doi: 10.4103/2225-4110.130374.

Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review.

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Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Sultanate of Oman. ; Ageing and Dementia Research Group, Sultan Qaboos University, Sultanate of Oman.
Ageing and Dementia Research Group, Sultan Qaboos University, Sultanate of Oman. ; College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India.


Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any sudden trauma/injury causes damage to the brain. TBI is characterized by tissue damage and imbalance in the cerebral blood flow and metabolism. It has been established through laboratory experiments that the dietary supplementation of omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, omega-3 FA intake could be considered as a therapeutic option to reduce the secondary neuronal damages initiated by TBI.


Brain trauma; Neuronal damage; Oman; Omega-3 fatty acids; Traumatic brain injury

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