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Cereb Cortex. 2015 Sep;25(9):3086-94. doi: 10.1093/cercor/bhu104. Epub 2014 May 23.

Thalamocortical Connectivity Correlates with Phenotypic Variability in Dystonia.

Author information

1
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.
2
Mirken Department of Neurology, Beth Israel Medical Center, New York, NY 10003, USA.
3
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Dystonia is a brain disorder characterized by abnormal involuntary movements without defining neuropathological changes. The disease is often inherited as an autosomal-dominant trait with incomplete penetrance. Individuals with dystonia, whether inherited or sporadic, exhibit striking phenotypic variability, with marked differences in the somatic distribution and severity of clinical manifestations. In the current study, we used magnetic resonance diffusion tensor imaging to identify microstructural changes associated with specific limb manifestations. Functional MRI was used to localize specific limb regions within the somatosensory cortex. Microstructural integrity was preserved when assessed in subrolandic white matter regions somatotopically related to the clinically involved limbs, but was reduced in regions linked to clinically uninvolved (asymptomatic) body areas. Clinical manifestations were greatest in subjects with relatively intact microstructure in somatotopically relevant white matter regions. Tractography revealed significant phenotype-related differences in the visualized thalamocortical tracts while corticostriatal and corticospinal pathways did not differ between groups. Cerebellothalamic microstructural abnormalities were also seen in the dystonia subjects, but these changes were associated with genotype, rather than with phenotypic variation. The findings suggest that the thalamocortical motor system is a major determinant of dystonia phenotype. This pathway may represent a novel therapeutic target for individuals with refractory limb dystonia.

KEYWORDS:

diffusion tensor imaging (DTI); dystonia; motor system; tractography

PMID:
24860017
PMCID:
PMC4537447
DOI:
10.1093/cercor/bhu104
[Indexed for MEDLINE]
Free PMC Article

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