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Nat Prod Bioprospect. 2014 Apr;4(2):113-8. doi: 10.1007/s13659-014-0013-7. Epub 2014 Apr 12.

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.

Author information

1
Veterinary Clinic for Pets, Müllheim/Baden, Germany.
2
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

Abstract

Artemisinin, a constituent of Artemisia annua L., is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.

KEYWORDS:

Artemisinin; Asteraceae; Comparative oncology; Scopoletin; Veterinary cancer

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