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Viruses. 2014 May 23;6(5):2155-85. doi: 10.3390/v6052155.

The DNA damage response induced by infection with human cytomegalovirus and other viruses.

Author information

1
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. xiaofei.e@umassmed.edu.
2
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA. timothy.kowalik@umassmed.edu.

Abstract

Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR). Many of these viruses use DDR signaling to benefit their replication, while other viruses block or inactivate DDR signaling. This review focuses on the effects of DDR and DNA repair on human cytomegalovirus (HCMV) replication. Here, we review the DDR induced by HCMV infection and its similarities and differences to DDR induced by other viruses. As DDR signaling pathways are critical for the replication of many viruses, blocking these pathways may represent novel therapeutic opportunities for the treatment of certain infectious diseases. Lastly, future perspectives in the field are discussed.

PMID:
24859341
PMCID:
PMC4036536
DOI:
10.3390/v6052155
[Indexed for MEDLINE]
Free PMC Article

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