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Exp Neurol. 2014 Nov;261:320-7. doi: 10.1016/j.expneurol.2014.05.010. Epub 2014 May 20.

Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.

Author information

1
Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy; Istituto Serafico, Assisi, Perugia, Italy.
2
Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy.
3
Fondazione Santa Lucia, IRCCS, Laboratory of Psychobiology, Rome, Italy.
4
Leibniz Institute for Neurobiology, Magdeburg, Germany.
5
Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.
6
Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy; Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy. Electronic address: paolo.calabresi@unipg.it.

Abstract

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.

KEYWORDS:

Bassoon; Environmental enrichment; Epilepsy; Hippocampus; Neurodevelopmental disorder; Synaptic plasticity

PMID:
24858730
DOI:
10.1016/j.expneurol.2014.05.010
[Indexed for MEDLINE]

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