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Mar Drugs. 2014 May 22;12(5):3060-71. doi: 10.3390/md12053060.

Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle.

Author information

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. tako0225j@gmail.com.
2
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. fangjungh@gmail.com.
3
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. jean801023@hotmail.com.
4
Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan. jackwei@gate.sinica.edu.tw.
5
Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan. nsyang@gate.sinica.edu.tw.
6
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.

Abstract

Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

PMID:
24857963
PMCID:
PMC4052331
DOI:
10.3390/md12053060
[Indexed for MEDLINE]
Free PMC Article
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