Format

Send to

Choose Destination
Arch Gerontol Geriatr. 2014 Sep-Oct;59(2):234-9. doi: 10.1016/j.archger.2014.04.011. Epub 2014 May 6.

Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review.

Author information

1
Institute of Biosciences, UNESP - Univ Estadual Paulista, Physical Activity and Aging Lab (LAFE), Avenida 24 A, 1515 - Bela Vista, Rio Claro, SP CEP 13506-900, Brazil. Electronic address: thaysmv@yahoo.com.br.
2
Institute of Biosciences, UNESP - Univ Estadual Paulista, Physical Activity and Aging Lab (LAFE), Avenida 24 A, 1515 - Bela Vista, Rio Claro, SP CEP 13506-900, Brazil.
3
Center of Mathematics, Computing and Cognition, UFABC, Federal University of ABC, Santo André, SP, Brazil.
4
Center of Mathematics, Computing and Cognition, UFABC, Federal University of ABC, Santo André, SP, Brazil; Institute of Biosciences, UNESP - Univ Estadual Paulista, Physical Activity and Aging Lab (LAFE), Avenida 24 A, 1515 - Bela Vista, Rio Claro, SP CEP 13506-900, Brazil.

Abstract

The aim of this study was to conduct a systematic review of studies that verified the effects of physical exercise on vascular endothelial growth factor (VEGF) in elderly.

METHODOLOGY:

The bibliographic search was conducted in five database, from 1990 to 2013, with the following keywords and boolean operators: physical exercise OR physical exercise OR physical therapy OR exercise OR training AND VEGF OR vascular endothelial growth factor AND aged OR older OR elderly. The inclusion criteria were: (1) sample including elderly with average age of 60; (2) studies that verified the effects of acute exercise; (3) studies that verified the effects of chronic physical exercise; (4) studies with humans; (5) randomized controlled trials, randomized non-controlled trials, non-randomized controlled trials, non-randomized and non-controlled trials; (6) assessment of VEGF peripheral concentrations.

RESULTS:

Ten studies were selected, and that four of them verified an increase of VEGF concentrations after practicing physical exercise and six studies did not verify any change on VEGF concentrations.

CONCLUSION:

Different populations found in this study and the different exercise protocols applied in the studies of this review make it difficult to establish parameters of what would be the best type of exercise to promote an increase on the concentrations of VEGF in the elderly. Therefore, we suggest that further studies can be performed, so that we can establish some recommendations for this population.

KEYWORDS:

Biomarkers; Exercise; Older people; Review; VEGF

PMID:
24856646
DOI:
10.1016/j.archger.2014.04.011
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center