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Med Clin (Barc). 2014 Aug 19;143(4):166-9. doi: 10.1016/j.medcli.2014.02.029. Epub 2014 May 22.

[Löfgren syndrome: a study of 80 cases].

[Article in Spanish]

Author information

1
Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: btejerasegura@gmail.com.
2
Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
3
Sección de Reumatología, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España; Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Pontevedra, España.
4
Sección de Reumatología, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.

Abstract

BACKGROUND AND OBJECTIVE:

Löfgren's syndrome is characterized by hiliar adenopathies, erythema nodosum and arthritis. It is a benign variant of sarcoidosis, common in the Mediterranean area. To describe the clinical characteristics, treatment and outcome of a series of patients diagnosed with Löfgren's syndrome.

PATIENTS AND METHODS:

Retrospective design (1984-2013).

SETTING:

Two university hospitals with a reference population of 1,015,000 inhabitants.

RESULTS:

Eighty patients were diagnosed: 29 men and 51 women (mean age 42.3 years). Forty eight patients (60%) presented with the classical triad: hiliar adenopathies, erythema nodosum and arthritis; 18 (22%) with hiliar adenopathy and arthritis; 13 (16%) hiliar adenopathies and erythema nodosum. All showed abnormalities in the chest study. According to the radiological pattern, patients were classified in stage i-ii. Biopsy was performed in 39 patients and was diagnostic in 28. Treatment was based on non-steroidal anti-inflammatory drugs (54 patients, 67%) and corticosteroids (33 patients, 41%). Fourteen patients (17%) suffered a recurrence of the disease.

CONCLUSIONS:

Löfgren's syndrome is a benign form of sarcoidosis with a well defined clinical pattern. Biopsy is usually not required. Recurrence is scarce. The disease has a good prognosis.

KEYWORDS:

Eritema nodoso; Erythema nodosum; Löfgren's síndrome; Sarcoidosis; Síndrome de Löfgren

Comment in

PMID:
24855899
DOI:
10.1016/j.medcli.2014.02.029
[Indexed for MEDLINE]

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