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Cancer J. 2014 May-Jun;20(3):181-9. doi: 10.1097/PPO.0000000000000048.

Microbiome, inflammation, and cancer.

Author information

1
From the Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA.

Abstract

Inflammation has long been suspected to play a major role in the pathogenesis of cancer. Only recently, however, have some mechanisms of its tumor promoting effects become known. Microbes, both commensal and pathogenic, are critical regulators of the host immune system and, ultimately, of inflammation. Consequently, microbes have the potential power to influence tumor progression as well, through a wide variety of routes, including chronic activation of inflammation, alteration of tumor microenvironment, induction of genotoxic responses, and metabolism. In this review, we will provide a general overview of commensal microbiota, inflammation, and cancer, as well as how microbes fit into this emerging field.

PMID:
24855005
PMCID:
PMC4112188
DOI:
10.1097/PPO.0000000000000048
[Indexed for MEDLINE]
Free PMC Article

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