Central and midperipheral corneal thickness measured with Scheimpflug imaging and optical coherence tomography

Jinhai Huang; Xixia Ding; Giacomo Savini; Zhengxuan Jiang; Chao Pan; Yanjun Hua; Fan Wu; Yifan Feng; Ye Yu; Qinmei Wang

doi:10.1371/journal.pone.0098316

Central and midperipheral corneal thickness measured with Scheimpflug imaging and optical coherence tomography

PLoS One. 2014 May 22;9(5):e98316. doi: 10.1371/journal.pone.0098316. eCollection 2014.

Authors

Jinhai Huang¹, Xixia Ding¹, Giacomo Savini², Zhengxuan Jiang³, Chao Pan⁴, Yanjun Hua⁴, Fan Wu⁴, Yifan Feng⁴, Ye Yu⁴, Qinmei Wang¹

Affiliations

¹ School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China.
² School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Studio Oculistico d'Azeglio, Bologna, Italy.
³ Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁴ School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Abstract

Purpose: To compare corneal thickness measurements using Pentacam (Oculus, Germany), Sirius (CSO, Italy), Galilei (Ziemer, Switzerland), and RTVue-100 OCT (Optovue Inc., USA).

Methods: Sixty-six eyes of 66 healthy volunteers were enrolled. Three consecutive measurements were performed with each device. The mean value of the three measurements was used for subsequent analysis. Central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT; measured at superior, inferior, nasal, and temporal locations with a distance of 1 mm (CT2mm) or 2.5 mm (CT5mm) from the corneal apex) were analyzed. Differences and agreement between measurements were assessed using the repeated-measures analysis of variance (ANOVA) and Bland-Altman analyses, respectively.

Results: Statistically significant differences (p<0.001) among the four devices were revealed in CCT, TCT and CT2mm measurements. The CCT, TCT, and CT2mm values were ranked from the thickest to the thinnest as follows: Galilei>Sirius>Pentacam>RTVue OCT. For these measurements, agreement between measurements by Sirius and Pentacam was good, whereas Galilei overestimated and RTVue underestimated corneal thickness compared to Sirius and Pentacam. As regards CT5mm measurements, Pentacam provided the largest values, whereas RTVue OCT yielded the smallest values. Agreement of the CT5mm measurements was good between the Pentacam, Sirius, moderate between Galilei and the other two Scheimpflug systems, and poor between the RTVue OCT and the remaining devices.

Conclusions: The Pentacam and Sirius can be used interchangeably for CCT measurements, while the Galilei and RTVue systematically over- and underestimate CCT, respectively. The three Scheimpflug cameras, but not the RTVue, may be used interchangeably for MPCT measurements.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Epithelium, Corneal / cytology*
Female
Healthy Volunteers
Humans
Male
Prospective Studies
Tomography, Optical Coherence*

Grants and funding

This work was supported in part by the Foundation of Wenzhou City Science & Technology Bureau (Y20110045; www.wzkj.gov.cn); the health Bureau of Zhejiang Province (2012KYB135; www.zjmed.org.cn); and the Scientific Research Fund of Zhejiang Provincial Education Department (Y201223147; www.zjedu.gov.cn). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.