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Mech Dev. 2014 Aug;133:117-25. doi: 10.1016/j.mod.2014.05.002. Epub 2014 May 20.

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.

Author information

1
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Graduate University of Chinese Academy of Sciences, Beijing, China.
2
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
3
Wenzhou Medical University, Zhejiang, China.
4
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
5
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: xinhua.lin@ioz.ac.cn.

Abstract

Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters.

KEYWORDS:

Drosophila; Hedgehog; Hyperplastic discs; Transcription; Ubiquitination

PMID:
24854243
PMCID:
PMC4351657
DOI:
10.1016/j.mod.2014.05.002
[Indexed for MEDLINE]
Free PMC Article
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