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Neuron. 2014 May 21;82(4):723-5. doi: 10.1016/j.neuron.2014.05.002.

Silencing synapses with DREADDs.

Author information

1
Department of Pharmacology, 4072 Genetic Medicine Building, UNC Chapel Hill Medical School, Chapel Hill, NC 27514, USA.
2
Department of Pharmacology, 4072 Genetic Medicine Building, UNC Chapel Hill Medical School, Chapel Hill, NC 27514, USA. Electronic address: bryan_roth@med.unc.edu.

Abstract

In this issue of Neuron, Stachniak et al. (2014) determine that the chemogenetic silencer hM4Di-DREADD suppresses presynaptic glutamate release, and by generating an axon-targeted hM4Di variant they demonstrate that it can be used to locally silence synaptic transmission in neural circuits.

PMID:
24853931
PMCID:
PMC4109642
DOI:
10.1016/j.neuron.2014.05.002
[Indexed for MEDLINE]
Free PMC Article
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