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PLoS Comput Biol. 2014 May 22;10(5):e1003520. doi: 10.1371/journal.pcbi.1003520. eCollection 2014 May.

The changing geometry of a fitness landscape along an adaptive walk.

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1
University of California, Merced, Merced, California, United States of America.

Abstract

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.

PMID:
24853069
PMCID:
PMC4031059
DOI:
10.1371/journal.pcbi.1003520
[Indexed for MEDLINE]
Free PMC Article
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