Allergy to formaldehyde: basophil histamine-release test is useful for diagnosis

Int Arch Allergy Immunol. 2014;164(1):27-9. doi: 10.1159/000361024. Epub 2014 May 13.

Abstract

We describe a case of formaldehyde-induced urticaria with a positive test result for serum IgE antibody against this substance. Formaldehyde's slow protein-binding property may explain why basophil histamine-release tests using fresh formaldehyde solutions are not diagnostic, whereas the tests are useful if formaldehyde that had been stored with albumin is used.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Albumins / immunology
  • Basophil Degranulation Test / methods*
  • Female
  • Fixatives / adverse effects*
  • Formaldehyde / adverse effects*
  • Formaldehyde / immunology
  • Humans
  • Hypersensitivity / diagnosis*
  • Hypersensitivity / etiology
  • Immunoglobulin E / blood

Substances

  • Albumins
  • Fixatives
  • Formaldehyde
  • Immunoglobulin E