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Trends Microbiol. 2014 Aug;22(8):473-82. doi: 10.1016/j.tim.2014.04.008. Epub 2014 May 19.

Reconstructing the evolutionary origins and phylogeography of hantaviruses.

Author information

1
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA; Department of Microbiology, California Academy of Sciences, San Francisco, CA, USA.
2
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA.
3
Division of Respiratory Viruses, Korea National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Korea.
4
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
5
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA; Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI, USA. Electronic address: ryanagih@hawaii.edu.

Abstract

Rodents have long been recognized as the principal reservoirs of hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne hantaviruses and newly detected non-rodent-borne hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses.

KEYWORDS:

Chiroptera; Eulipotyphla; evolution; hantavirus; host-switching

PMID:
24852723
PMCID:
PMC4135427
DOI:
10.1016/j.tim.2014.04.008
[Indexed for MEDLINE]
Free PMC Article
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