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Pediatr Hematol Oncol. 2014 Sep;31(6):534-47. doi: 10.3109/08880018.2014.915443. Epub 2014 May 22.

ITP-QoL questionnaire for children with immune thrombocytopenia: Italian version validation's.

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1
Department of Biomedical Sciences and Human Oncology, Pediatric Unit "F. Vecchio", University of Bari "Aldo Moro" , Bari , Italy.

Abstract

BACKGROUND:

The ITP-QoL is a disease-specific questionnaire for the assessment of health-related quality of life (HRQoL) in children with immune thrombocytopenia (ITP) and their parents. The aim of this study was to test the psychometric characteristics of the ITP-QoL in the Italian pediatric population in terms of validity and reliability.

PROCEDURE:

Children aged 8-16 years with acute or chronic ITP and their parents were recruited in Italy. Participants completed the ITP-QoL together with other patient-reported outcomes (PROs). Reliability was calculated using Cronbach's alpha. Convergent validity was determined by means of the Pearson correlation coefficients.

RESULTS:

A total of 91 ITP patients, mean age of 12.11 ± 2.47 years, and their parents participated; 61.5% of the patients were female. Two patients had acute ITP and 30.2% had a moderate to severe status of ITP. Cutaneous symptoms were more frequent than mucosal symptoms. Due to item and scale analyses 20 items were deleted from the original ITP-QoL. Internal consistency of the ITP-QoL was found to be good with Cronbach's alpha exceeding α = 0.70 for all but one subscale. Concerning convergent validity "moderate" to "high" negative correlations were found between ITP-QoL and KINDL subscales. The ITP-QoL was able to discriminate between clinical subgroups such as number of days lost at school due to ITP and hospitalization.

CONCLUSIONS:

Our study was able to demonstrate that the Italian version of ITP-QoL (for children aged 8-16 years) is a valid and reliable instrument for the assessment of HRQoL in children with ITP.

KEYWORDS:

Italy; children; immune thrombocytopenia (ITP); psychometric testing; quality of life

PMID:
24852656
DOI:
10.3109/08880018.2014.915443
[Indexed for MEDLINE]
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