Format

Send to

Choose Destination
Cancer Res Treat. 2014 Apr;46(2):158-64. doi: 10.4143/crt.2014.46.2.158. Epub 2014 Apr 22.

Clinical outcomes of local excision following preoperative chemoradiotherapy for locally advanced rectal cancer.

Author information

1
Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea. ; Department Radiation Oncology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
2
Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea. ; Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
3
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
4
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
5
Department of Radiation Oncology, Chonnam National University Ewha Womans University Mokdong Hospital, Gwangju, Korea.
6
Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.

Abstract

PURPOSE:

To evaluate the treatment outcomes of local excision following preoperative chemoradiotherapy in patients with locally advanced rectal cancer who have not undergone radical surgery for any reason.

MATERIALS AND METHODS:

The data of 27 patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy followed by local excision were analyzed retrospectively. The primary endpoint was the 5-year relapse-free survival rate, and the secondary endpoint was the pattern of recurrence.

RESULTS:

The median follow-up time was 81.8 months (range, 28.6 to 138.5 months). The 5-year local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS) were 88.9%, 81.1%, 77.8%, and 85.0%, respectively. Six (22%) patients developed treatment failure; one (4%) patient had local recurrence only, three (11%) patients had distant recurrence only, and two (7%) patients had both. The 5-year LRFS, DMFS, RFS, and OS for patients with ypT0-1 compared with ypT2-3 were 94.1% vs. 77.8% (p=0.244), 94.1% vs. 55.6% (p=0.016), 88.2% vs. 55.6% (p=0.051), and 94.1% vs. 66.7% (p=0.073), respectively.

CONCLUSION:

Local excision following preoperative chemoradiotherapy may be an alternative treatment for highly selected patients with locally advanced rectal cancer who have achieved ypT0-1 after preoperative chemoradiotherapy.

KEYWORDS:

Local excision; Preoperative chemoradiotherapy; Rectal neoplasms; Survival

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center