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Korean J Intern Med. 2014 May;29(3):383-7. doi: 10.3904/kjim.2014.29.3.383. Epub 2014 Apr 29.

Distant subcutaneous recurrence of a parathyroid carcinoma: abnormal uptakes in the (99m)Tc-sestamibi scan and (18)F-FDG PET/CT imaging.

Author information

1
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
2
Department of Nuclear Medicine, Pusan National University School of Medicine, Busan, Korea.

Abstract

We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50-year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a (99m)Tc-sestamibi scan, and (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) imaging demonstrated a subcutaneous mass. She underwent tumor resection, and the pathological findings were consistent with a parathyroid carcinoma. The postoperative serum parathyroid hormone (PTH) level remained within normal limits. However, a new palpable solitary mass was identified in the upper portion of the left breast 1 year postoperatively. Both a (99m)Tc-sestamibi scan and (18)F-FDG PET/CT imaging revealed an abnormal lesion in the upper breast, and subsequent pathology reports confirmed parathyroid carcinoma metastasis. Serum PTH and calcium levels fell within normal ranges after tumor resection. Two subcutaneous recurrent lesions appeared likely due to tumor seeding during the previous endoscopic operation at a local hospital.

KEYWORDS:

Hyperparathyroidism; Neoplasm recurrence; Parathyroid neoplasms; Positron-emission tomography

PMID:
24851075
PMCID:
PMC4028530
DOI:
10.3904/kjim.2014.29.3.383
[Indexed for MEDLINE]
Free PMC Article
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