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J Nat Prod. 2014 Jun 27;77(6):1420-9. doi: 10.1021/np500145f. Epub 2014 May 21.

Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutum.

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1
Department Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstrasse 7, 38124 Braunschweig, Germany.

Abstract

Seven new polyketides, for which the trivial names hyafurones A1-B (1-3), hyapyrrolines A (4) and B (5), and hyapyrones A (6) and B (7) are proposed, were isolated from the fermentation broth of the myxobacteria Hyalangium minutum, strains NOCB-2(T) and Hym-3. Their structures were elucidated from NMR and HRESIMS data, and their geometric configuration was assigned based on NOE and vicinal (1)H coupling data. Both hyafurone B (3) and hyapyrone B (7) inhibited growth of the Gram-positive bacterium Nocardia flava, while 7 showed antifungal activity against Mucor hiemalis.

PMID:
24848583
DOI:
10.1021/np500145f
[Indexed for MEDLINE]
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