Format

Send to

Choose Destination
Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):324-8. doi: 10.1097/MCO.0000000000000065.

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases.

Author information

1
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

PURPOSE OF REVIEW:

Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered.

RECENT FINDINGS:

A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging.

SUMMARY:

Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.

PMID:
24848532
DOI:
10.1097/MCO.0000000000000065
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center