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PLoS One. 2014 May 21;9(5):e98076. doi: 10.1371/journal.pone.0098076. eCollection 2014.

Genome-wide analysis of cold adaptation in indigenous Siberian populations.

Author information

1
Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom.
2
Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
3
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
4
Department of Mathematics, University of Bristol, Bristol, United Kingdom.
5
National Cancer Centre Singapore, Singapore, Singapore.
6
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.
7
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.
8
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia.
9
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
10
Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
11
Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia.
12
Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom; Estonian Biocentre, Tartu, Estonia.

Abstract

Following the dispersal out of Africa, where hominins evolved in warm environments for millions of years, our species has colonised different climate zones of the world, including high latitudes and cold environments. The extent to which human habitation in (sub-)Arctic regions has been enabled by cultural buffering, short-term acclimatization and genetic adaptations is not clearly understood. Present day indigenous populations of Siberia show a number of phenotypic features, such as increased basal metabolic rate, low serum lipid levels and increased blood pressure that have been attributed to adaptation to the extreme cold climate. In this study we introduce a dataset of 200 individuals from ten indigenous Siberian populations that were genotyped for 730,525 SNPs across the genome to identify genes and non-coding regions that have undergone unusually rapid allele frequency and long-range haplotype homozygosity change in the recent past. At least three distinct population clusters could be identified among the Siberians, each of which showed a number of unique signals of selection. A region on chromosome 11 (chr11:66-69 Mb) contained the largest amount of clustering of significant signals and also the strongest signals in all the different selection tests performed. We present a list of candidate cold adaption genes that showed significant signals of positive selection with our strongest signals associated with genes involved in energy regulation and metabolism (CPT1A, LRP5, THADA) and vascular smooth muscle contraction (PRKG1). By employing a new method that paints phased chromosome chunks by their ancestry we distinguish local Siberian-specific long-range haplotype signals from those introduced by admixture.

PMID:
24847810
PMCID:
PMC4029955
DOI:
10.1371/journal.pone.0098076
[Indexed for MEDLINE]
Free PMC Article

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