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Front Genet. 2014 May 9;5:122. doi: 10.3389/fgene.2014.00122. eCollection 2014.

The first international mini-symposium on methionine restriction and lifespan.

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Orentreich Foundation for the Advancement of Science, Cold Spring NY, USA.
School of Medicine & Health Sciences, University of North Dakota, Grand Forks ND, USA.
University of Texas Health Science Center at San Antonio, San Antonio TX, USA.
Harwell Science and Innovation Campus Oxfordshire, UK.
Department of Pharmacology, University of Oxford Oxford, UK ; Department of Physiology, University of Alexandria Alexandria, Egypt.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston MA, USA.
Institute of Physical Education, Health and Leisure Studies, National Cheng Kung University Tainan, Taiwan.
Geriatrics Center and Institute of Gerontology, University of Michigan, Ann Arbor MI, USA.
Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University Boston, MA, USA.
Public Health Sciences, College of Medicine, Penn State University Hershey, PA, USA.
University of Connecticut Health Center, Farmington CT, USA.
Division of Nutritional Sciences, Cornell University Ithaca, NY, USA.


It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et al., 1993). Since then, several studies have replicated the effects of dietary methionine restricted (MR) in delaying age-related diseases (Richie et al., 1994; Miller et al., 2005; Ables et al., 2012; Sanchez-Roman and Barja, 2013). We report the abstracts from the First International Mini-Symposium on Methionine Restriction and Lifespan held in Tarrytown, NY, September 2013. The goals were (1) to gather researchers with an interest in MR and lifespan, (2) to exchange knowledge, (3) to generate ideas for future investigations, and (4) to strengthen relationships within this community. The presentations highlighted the importance of research on cysteine, growth hormone (GH), and ATF4 in the paradigm of aging. In addition, the effects of dietary restriction or MR in the kidneys, liver, bones, and the adipose tissue were discussed. The symposium also emphasized the value of other species, e.g., the naked mole rat, Brandt's bat, and Drosophila, in aging research. Overall, the symposium consolidated scientists with similar research interests and provided opportunities to conduct future collaborative studies (Figure 3).


aging and longevity; animal models; lifespan; methionine restriction

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