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Cell Mol Neurobiol. 2014 Aug;34(6):797-804. doi: 10.1007/s10571-014-0070-9. Epub 2014 May 21.

Anti-apoptotic and anti-oxidative roles of quercetin after traumatic brain injury.

Author information

1
Department of Neurosurgery, Chengdu Military General Hospital, No. 270, Rong Du Road, Chengdu, 610083, Sichuan, China.

Abstract

Experimental studies have demonstrated significant secondary damage (including cell apoptosis, blood-brain barrier disruption, inflammatory responses, excitotoxic damage, and free radical production) after traumatic brain injury (TBI). Quercetin is a natural flavonoid found in high quantities in fruits and vegetables, and may be a potential antioxidant and free radical scavenger. The purpose of this study was to determine the effects of quercetin on TBI-induced upregulation of oxidative stress, inflammation, and apoptosis in adult Sprague-Dawley rats. Animals were subjected to Feeney's weight-drop injury, thus inducing the parietal contusion brain injury model. Quercetin was administered (30 mg/kg intraperitoneal injection) 0, 24, 48, and 72 h after TBI. Quercetin reduced cognitive deficits, the number of TUNEL- and ED-1-positive cells, the protein expressions of Bax and cleaved-caspase-3 proteins, and the levels of TBARS and proinflammatory cytokines, and increased the activity of antioxidant enzymes (GSH-Px, SOD, and CAT) at 1 week after TBI. Our results suggest that in TBI rats, quercetin improves cognitive function owing to its neuroprotective action via the inhibition of oxidative stress, leading to a reduced inflammatory response, thereby reducing neuronal death.

PMID:
24846663
DOI:
10.1007/s10571-014-0070-9
[Indexed for MEDLINE]

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