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Contemp Clin Trials. 2014 Jul;38(2):251-9. doi: 10.1016/j.cct.2014.05.007. Epub 2014 May 17.

Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol.

Author information

1
Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL 60611, United States. Electronic address: c-pellegrini@northwestern.edu.
2
Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL 60611, United States.
3
The Methodology Center, Department of Human Development & Family Studies, 400 Calder Square II, The Pennsylvania State University, University Park, PA 16801, United States.

Erratum in

  • Contemp Clin Trials. 2015 Nov;45(Pt B):468-9.

Abstract

BACKGROUND:

Obesity-attributable medical expenditures remain high, and interventions that are both effective and cost-effective have not been adequately developed. The Opt-IN study is a theory-guided trial using the Multiphase Optimization Strategy (MOST) to develop an optimized, scalable version of a technology-supported weight loss intervention.

OBJECTIVE:

Opt-IN aims to identify which of 5 treatment components or component levels contribute most meaningfully and cost-efficiently to the improvement of weight loss over a 6 month period.

STUDY DESIGN:

Five hundred and sixty obese adults (BMI 30-40 kg/m(2)) between 18 and 60 years old will be randomized to one of 16 conditions in a fractional factorial design involving five intervention components: treatment intensity (12 vs. 24 coaching calls), reports sent to primary care physician (No vs. Yes), text messaging (No vs. Yes), meal replacement recommendations (No vs. Yes), and training of a participant's self-selected support buddy (No vs. Yes). During the 6-month intervention, participants will monitor weight, diet, and physical activity on the Opt-IN smartphone application downloaded to their personal phone. Weight will be assessed at baseline, 3, and 6 months.

SIGNIFICANCE:

The Opt-IN trial is the first study to use the MOST framework to develop a weight loss treatment that will be optimized to yield the best weight loss outcome attainable for $500 or less.

KEYWORDS:

Optimization; Technology; Weight loss

PMID:
24846621
PMCID:
PMC4104542
DOI:
10.1016/j.cct.2014.05.007
[Indexed for MEDLINE]
Free PMC Article

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