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Curr Biol. 2014 May 19;24(10):R424-34. doi: 10.1016/j.cub.2014.03.023.

Stress-induced remodeling of the bacterial proteome.

Author information

1
Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158, USA.
2
Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158, USA. Electronic address: cgrossucsf@gmail.com.

Abstract

Microorganisms live in fluctuating environments, requiring stress response pathways to resist environmental insults and stress. These pathways dynamically monitor cellular status, and mediate adaptive changes by remodeling the proteome, largely accomplished by remodeling transcriptional networks and protein degradation. The complementarity of fast, specific proteolytic degradation and slower, broad transcriptomic changes gives cells the mechanistic repertoire to dynamically adjust cellular processes and optimize response behavior. Together, this enables cells to minimize the 'cost' of the response while maximizing the ability to survive environmental stress. Here we highlight recent progress in our understanding of transcriptional networks and proteolysis that illustrates the design principles used by bacteria to generate the complex behaviors required to resist stress.

PMID:
24845675
PMCID:
PMC4089988
DOI:
10.1016/j.cub.2014.03.023
[Indexed for MEDLINE]
Free PMC Article

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