Delivering the second revolution in site-specific nucleases

Elife. 2014 May 8:3:e02904. doi: 10.7554/eLife.02904.

Abstract

Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.

Keywords: gag; gene therapy; lentiviral vector; protein transduction; transcription activator-like effector nucleases; zinc-finger nucleases.

Publication types

  • Comment

MeSH terms

  • Endonucleases / biosynthesis*
  • Genetic Engineering / methods*
  • Genetic Vectors*
  • Genome, Human*
  • Humans
  • Lentivirus / metabolism*
  • Transcription Factors / biosynthesis*
  • Transduction, Genetic*
  • Transfection / methods*

Substances

  • Transcription Factors
  • Endonucleases