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Fertil Steril. 2014 Jul;102(1):3-9. doi: 10.1016/j.fertnstert.2014.04.018. Epub 2014 May 17.

Clinical rationale for cryopreservation of entire embryo cohorts in lieu of fresh transfer.

Author information

1
Fertility Center of Las Vegas, Las Vegas, Nevada; Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada. Electronic address: bsshapiro@aol.com.
2
Fertility Center of Las Vegas, Las Vegas, Nevada; Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada.
3
Fertility Center of Las Vegas, Las Vegas, Nevada.

Abstract

Recent dramatic increases in success rates with frozen-thawed embryo transfer (FET) are encouraging, as are numerous findings of several reduced risks with FET when compared with fresh transfer. These reduced risks include low birth weight and prematurity, among others. However, FET is also associated with increased risks of macrosomia and large for gestational age. There have been reports of greater implantation and pregnancy rates with FET than with fresh autologous embryo transfer, suggesting superior endometrial receptivity in the absence of ovarian stimulation. As cryo-technology evolves, there is potential for further increase in FET success rates, but for now it may be best to follow an individualized approach, balancing fresh transfer and embryo cohort cryopreservation options while considering patient characteristics, cycle parameters, and clinic success rates.

KEYWORDS:

In vitro fertilization; embryo cryopreservation; frozen embryo transfer; ovarian stimulation; perinatal risk

[Indexed for MEDLINE]

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