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FEBS Lett. 2014 Jun 27;588(14):2238-45. doi: 10.1016/j.febslet.2014.05.002. Epub 2014 May 17.

Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC.

Author information

1
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China.
2
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China. Electronic address: YJChen@NJMU.edu.cn.

Abstract

Aberrant expression of microRNAs has been shown to regulate the biological processes of lung cancer cells. However, the role of miR-638 in the development of NSCLC is still unclear. In this study, low miR-638 and high SOX2 were shown to be associated with tumor size and metastasis of NSCLC patients. Downregulated miR-638 could promote cell invasion and proliferation, while high miR-638 expression reversed the effect. Furthermore, miR-638 could regulate SOX2 by directly binding to its 3'-UTR. Silencing of SOX2 by siRNA partially abolished the enhancement of cell invasion and proliferation induced by downregulated miR-638. Aberrant miR-638 expression could modulate the expression levels of markers of epithelial-to-mesenchymal transition. Our results indicate that miR-638 may play a pivotal role in the development of NSCLC.

KEYWORDS:

Epithelial-to-mesenchymal transition; Invasion; Non-small-cell lung cancer; Proliferation; SRY (sex determining region Y)-box 2; miR-638

PMID:
24842609
DOI:
10.1016/j.febslet.2014.05.002
[Indexed for MEDLINE]
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