Format

Send to

Choose Destination
See comment in PubMed Commons below
BMJ Case Rep. 2014 May 19;2014. pii: bcr2014204138. doi: 10.1136/bcr-2014-204138.

Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia.

Author information

1
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
2
Eye Clinic, Hakodate Goryokaku Hospital, Hakodate, Japan.
3
Department of College of Medicine, Texas A&M Health Science Center, Texas A&M University, Temple, Texas, USA.

Abstract

Ligneous conjunctivitis is a rare severe conjunctivitis characterised by fibrin-rich, 'woody', pseudomembranes on the tarsal conjunctiva complicated by congenital hypoplasminogenaemia. A previous report suggested that ligneous conjunctivitis may result from tranexamic acid (TA)-induced 'secondary' hypoplasminogenaemia. However, the serum plasminogen level has not been confirmed in that scenario. We report for the first time a case of TA-induced ligneous conjunctivitis with reversible hypoplasminogenaemia. A 70-year-old woman developed a gastric ulcer that was treated with oral TA. After 5 weeks of treatment, the patient presented with bilateral pale yellow pseudomembranes on the palpebral conjunctivae. Haematological analysis showed hypoplasminogenaemia. We diagnosed ligneous conjunctivitis. TA was discontinued after 14 weeks after the gastric ulcer symptoms resolved. Six weeks after discontinuation of therapy, the pseudomembranes regressed and the serum plasminogen level returned to the normal range. TA should be considered a possible aetiology in the setting of unresolving ligneous conjunctivitis.

PMID:
24842363
PMCID:
PMC4039943
DOI:
10.1136/bcr-2014-204138
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center