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ACS Chem Biol. 2014 Jul 18;9(7):1432-6. doi: 10.1021/cb500172u. Epub 2014 May 22.

Synthetic versus natural receptors: supramolecular control of chemical sensing in fish.

Author information

1
CIQA, Faculdade de Ciências e Tecnologia and ⊥CCMAR, Universidade do Algarve , Campus de Gambelas 8005-139 Faro Portugal.

Abstract

The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.

PMID:
24841288
DOI:
10.1021/cb500172u
[Indexed for MEDLINE]

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