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Nat Immunol. 2014 Jun;15(6):503-11. doi: 10.1038/ni.2891.

Translational control of immune responses: from transcripts to translatomes.

Author information

1
1] Department of Microbiology and Immunology, and Microbiome and Disease Tolerance Centre, McGill University, Montreal, Canada. [2] FOCIS Centre of Excellence and Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
2
Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
3
1] Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montréal, Canada. [2] Department of Oncology, McGill University, Montréal, Canada.
4
Department of Biochemistry, and Goodman Cancer Research Centre, McGill University, Montreal, Canada.

Abstract

Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent. Studies of 'translatomes' (genome-wide pools of translated mRNA) have facilitated mechanistic discoveries by identifying key regulatory components, including transcription factors, that are under translational control. Here we review the current knowledge on mechanisms that regulate translation and thereby modulate immunological function. We further describe approaches for measuring and analyzing translatomes and how such powerful tools can facilitate future insights on the role of translational control in the immune system.

PMID:
24840981
DOI:
10.1038/ni.2891
[Indexed for MEDLINE]
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