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Nat Immunol. 2014 Jun;15(6):492-502. doi: 10.1038/ni.2884.

Post-transcriptional coordination of immunological responses by RNA-binding proteins.

Author information

1
Division of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.

Abstract

Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies engaged in the coordinative regulation of state-specific RNAs indicates alternative and exclusive means for determining the activation, plasticity and tolerance of cells of the immune system. Here we review current knowledge about RBP-regulated post-transcriptional events involved in the reactivity of cells of the immune system and the importance of their alteration during chronic inflammatory pathology and autoimmunity.

PMID:
24840980
DOI:
10.1038/ni.2884
[Indexed for MEDLINE]

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