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Prim Care Diabetes. 2015 Feb;9(1):39-47. doi: 10.1016/j.pcd.2014.04.007. Epub 2014 May 17.

Cost-effectiveness of dapagliflozin (Forxiga®) added to metformin compared with sulfonylurea added to metformin in type 2 diabetes in the Nordic countries.

Author information

1
AstraZeneca, Södertälje, Sweden. Electronic address: ugne.sabale@astrazeneca.com.
2
AstraZeneca, Södertälje, Sweden.
3
AstraZeneca, Mölndal, Sweden.
4
Health Economics and Outcomes Research Ltd., Monmouth, UK; Centre for Health Economics, Swansea University, UK.

Abstract

AIMS:

The aim of this study was to assess the long-term cost-effectiveness of dapagliflozin (Forxiga(®)) added to metformin, compared with sulfonylurea (SU) added to metformin, in Nordic Type 2 diabetes mellitus (T2DM) patients inadequately controlled on metformin.

METHODS:

Data from a 52-week clinical trial comparing dapagliflozin and SU in combination with metformin was used in a Cardiff simulation model to estimate long term diabetes-related complications in a cohort of T2DM patients. Costs and QALYs were calculated from a healthcare provider perspective and estimated over a patient's lifetime.

RESULTS:

Compared with metformin+SU, the cost per QALY gained with dapagliflozin+metformin was €7944 in Denmark, €5424 in Finland, €4769 in Norway, and €6093 in Sweden. Metformin+dapagliflozin was associated with QALY gains ranging from 0.236 in Norway to 0.278 in Sweden and incremental cost ranging from €1125 in Norway to €1962 in Denmark. Results were robust across both one-way and probabilistic sensitivity analyses. Results were driven by weight changes associated with each treatment.

CONCLUSIONS:

Results indicate that metformin+dapagliflozin is associated with gains in QALY compared with metformin+SU in Nordic T2DM patients inadequately controlled on metformin. Dapagliflozin treatment is a cost-effective treatment alternative for Type 2 diabetes in all four Nordic countries.

KEYWORDS:

Cost-effectiveness; Dapagliflozin; Economic modeling; Sulfonylurea; Type 2 diabetes mellitus

PMID:
24840612
DOI:
10.1016/j.pcd.2014.04.007
[Indexed for MEDLINE]

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