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Cancer Biol Ther. 2014 Aug;15(8):963-7. doi: 10.4161/cbt.29188. Epub 2014 May 19.

Pancreatic Cancer Database: an integrative resource for pancreatic cancer.

Author information

1
Institute of Bioinformatics; International Technology Park; Bangalore, India; Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
2
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Biological Chemistry; Johns Hopkins University School of Medicine; Baltimore, MD USA.
3
Institute of Bioinformatics; International Technology Park; Bangalore, India.
4
Institute of Bioinformatics; International Technology Park; Bangalore, India; Department of Biochemistry and Molecular Biology; School of Life Sciences; Pondicherry University; Puducherry, India.
5
Institute of Bioinformatics; International Technology Park; Bangalore, India; Bioinformatics Centre; School of Life Sciences; Pondicherry University; Puducherry, India.
6
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA.
7
Armed Forces Medical College; Pune, India.
8
Government Medical College and Hospital; Chandigarh, India.
9
Amrita School of Biotechnology; Amrita Vishwa Vidyapeetham; Kollam, Kerala India.
10
Departments of Pathology and Translational Molecular Pathology; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research; UT MD Anderson Cancer Center; Houston, TX USA.
11
Department of Pathology; Sol Goldman Pancreatic Cancer Research Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA.
12
McKusick-Nathans Institute of Genetic Medicine; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Biological Chemistry; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Pathology; Sol Goldman Pancreatic Cancer Research Center; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA.

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.

KEYWORDS:

biomarker; body fluids; chronic pancreatitis; secreted

PMID:
24839966
PMCID:
PMC4119079
DOI:
10.4161/cbt.29188
[Indexed for MEDLINE]
Free PMC Article

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