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Cell Res. 2014 Aug;24(8):908-9. doi: 10.1038/cr.2014.66. Epub 2014 May 20.

Regulating the regulator of ROS production.

Author information

1
1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Department of Medicine, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [3] Department of Pathology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.
2
1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Center for Lung and Vascular Biology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

Abstract

Balancing inflammatory reactive oxygen species (ROS) production is essential for safely eliminating pathogenic microbes. The newly described protein Negative Regulator of ROS (NRROS) dampens ROS production by restricting NOX2 availability, and thus "cools-off" inflammation.

PMID:
24839902
PMCID:
PMC4123290
DOI:
10.1038/cr.2014.66
[Indexed for MEDLINE]
Free PMC Article

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