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Can Urol Assoc J. 2014 Mar;8(3-4):E263-5. doi: 10.5489/cuaj.1648.

Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate.

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Department of Urology, Kitasato University School of Medicine, Japan;
Department of Pharmacology, Kitasato University School of Medicine, Japan;
Department of Pathology, Kitasato University School of Medicine, Japan.


A 22-year-old man was referred to our hospital with macroscopic hematuria and consistent anal pain. Magnetic resonance imaging revealed an enlarged prostate tumour invading the bladder and rectum. A biopsy revealed an unclassified spindle cell sarcoma. Subsequently, radical cystoprostatectomy and resection of the rectum were performed. A histopathological examination revealed a prostatic malignant phyllodes tumour with a negative surgical margin. However, a local recurrence was identified 2 months after surgery. Induction therapy included 4 cycles of systemic chemotherapy comprising etoposide with ifosfamide and cisplatin. Although a partial response was observed at the local site, lung metastasis developed. Second-line chemotherapy with ifosfamide and doxorubicin with radiotherapy to the pelvis was administered and led to complete regression; however, its efficacy was transient. Although additional chemotherapy was administered, the patient eventually died due to the rapidly growing, recurrent tumour.

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