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Methods Mol Biol. 2014;1151:3-25. doi: 10.1007/978-1-4939-0554-6_1.

Recent progress in engineering human-associated microbiomes.

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1
Program in Medical Engineering Medical Physics, Harvard-MIT Health Sciences and Technology, Cambridge, MA, USA.

Abstract

Recent progress in molecular biology and genetics opens up the possibility of engineering a variety of biological systems, from single-cellular to multicellular organisms. The consortia of microbes that reside on the human body, the human-associated microbiota, are particularly interesting as targets for forward engineering and manipulation due to their relevance in health and disease. New technologies in analysis and perturbation of the human microbiota will lead to better diagnostic and therapeutic strategies against diseases of microbial origin or pathogenesis. Here, we discuss recent advances that are bringing us closer to realizing the true potential of an engineered human-associated microbial community.

PMID:
24838875
DOI:
10.1007/978-1-4939-0554-6_1
[Indexed for MEDLINE]
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