Format

Send to

Choose Destination
Neurology. 2014 Jun 17;82(24):2165-72. doi: 10.1212/WNL.0000000000000522. Epub 2014 May 16.

Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions.

Author information

1
From the Department of Ophthalmology (A.K., N.V.) and the Brain and Mind Institute (C.W., M.H.B., L.M.), University of Sydney; the Australian School of Advanced Medicine (A.K., P.S., S.L.G.), Macquarie University; St. Vincent Hospital (R.G.); North Shore Hospital (J.P.), Sydney, Australia; Hadassah Hebrew University Medical Center (N.L., N.R.), Jerusalem, Israel; the Department of Neurology (A.V.d.W.), Royal Melbourne Hospital; and Concord Hospital (C.Y.), Sydney, Australia. sasha@eye.usyd.edu.au.
2
From the Department of Ophthalmology (A.K., N.V.) and the Brain and Mind Institute (C.W., M.H.B., L.M.), University of Sydney; the Australian School of Advanced Medicine (A.K., P.S., S.L.G.), Macquarie University; St. Vincent Hospital (R.G.); North Shore Hospital (J.P.), Sydney, Australia; Hadassah Hebrew University Medical Center (N.L., N.R.), Jerusalem, Israel; the Department of Neurology (A.V.d.W.), Royal Melbourne Hospital; and Concord Hospital (C.Y.), Sydney, Australia.

Abstract

OBJECTIVE:

To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway.

METHODS:

Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sex-matched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenuated inversion recovery lesions and diffusion tensor imaging (DTI) indices were measured within both structures. Cross-sectional diameter of the OT was also calculated.

RESULTS:

tRNFL thickness was significantly reduced in NON eyes and was associated with reduced low-contrast visual acuity. Lesions within the OR were detected in the majority of patients. There was a significant correlation between thinning of the tRNFL and OR lesion volume (adjusted for non-OR lesion volume, age, sex, and disease duration). tRNFL thickness also correlated with OR DTI indices. No OT lesions were identified in any of the patients and no relationship between retinal nerve fiber layer loss and potential markers of OT lesions was found.

CONCLUSION:

The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR.

PMID:
24838786
PMCID:
PMC4113462
DOI:
10.1212/WNL.0000000000000522
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center